Carisoprodol is a centrally acting muscle relaxant that does not directly relax tense skeletal muscles in a person. The mode of action of Carisoprodol in relieving acute muscular spasm of local origin has not been clearly identified, but may be related to its sedative properties. In animals, carisoprodolhas been shown to relax the muscles by blocking interneuron activity and inhibiting the transmission of polysynaptic neurons in the spinal cord and in descending reticular brain formation. The onset of action is quick and lasts four to six hours.
Carisoprodol is absorbed in the liver and excreted by the kidneys. It is dialyzable by peritoneal and haemodialysis.
Aspirin is a non-narcotic analgesic with anti-inflammatory and antipyretic activity. The inhibition of prostaglandin biosynthesis seems to constitute a large part of its anti-inflammatory agent and for at least part of its analgesic and antipyretic properties.
Aspirin is rapidly absorbed and is almost completely hydrolysed to salicylic acid after oral administration. Although aspirin has a half-life of only about 15 minutes, the apparent biological half-life of salicylic acid in the therapeutic plasma concentration range is between 6 and 12 hours. Salicylic acid is eliminated by renal excretion and biotransformation to the inactive metabolite. Salicylic acid clearance in the high dose range is sensitive to urinary pH (see Drug Interactions), and is reduced by renal dysfunction.
Codeine phosphate: Codeine phosphate is a centrally acting narcotic analgesic. Her actions are qualitatively similar to morphine, but her potency is substantially less.
Clinical studies have shown that combining aspirin and codeine has a significant additional effect on analgesic efficacy.
INDICATIONS AND USAGE – The ‘Soma’ complex with Codeine is indicated as an adjunct to rest, physiotherapy and other measures to relieve pain, muscle spasm and limited mobility associated with acute, painful musculoskeletal conditions when additional action of codeine is desired.
CONTRAINDICATIONS – Acute unstable porphyria; bleeding disorders; allergic or specific reactions to carisoprodol, aspirin, codeine, or related complexes.
WARNINGS – In very rare cases, the first dose of carisoprodolhas been accompanied by specific reactions with symptoms appearing within minutes or hours. They may include extreme weakness, transient quadriplegia, dizziness, ataxia, temporary loss of vision, diplopia, mydriasis, dysarthria, agitation, euphoria, confusion and disorientation. Although the symptoms usually subside over the next few hours, the Soma Complex with Codeine is discontinued and adequate and symptomatic support therapy is initiated, which may include adrenaline and / or antihistamines. In severe cases, corticosteroids may be necessary. Severe reactions were manifested by asthmatic episodes, fever, weakness, dizziness, angioedema, eyes, hypotension and anaphylactic shock.
The effects of carisoprodol with substances such as alcohol, other central nervous system depressants or psychotropic drugs may be additional. Adequate caution must be exercised with patients taking one or more of these agents simultaneously with the Soma Complex with Codeine.
Contains sodium metabisulfate, sulphite, which can cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulphite sensitivity in the general population is unknown and probably low. Sulphur sensitivity is seen more often in asthmatics than in non-asthmatic people.
GENERAL PRECAUTIONS: To avoid excessive accumulation of carisoprodol, aspirin or their metabolites, use Soma Complex with Codeine with caution in patients with compromised liver or kidney function, or in elderly or debilitated patients / Use with caution in patients with a history of gastritis or peptic ulcer, in patients on anticoagulant therapy, and in people prone to addiction.